【作者】 李杨； 王鹏； 吉民； 顾宁；

【Author】 LI Yang;WANG Peng;JI Min;GU Ning;Key Laboratory for Biomaterials and Devices of JiangSu Province,Southeast University;College of Chemistry and Chemical Engineering,Southeast University;

【机构】 东南大学江苏省生物材料与器件重点实验室； 东南大学化学化工学院；

【摘要】 目的:合成稳定性好的零价铁纳米颗粒,并探究不同条件对合成零价纳米铁颗粒形貌的影响。方法:本文主要基于液相还原法,研究以NaBH4还原剂将Fe3+还原出来,形成零价铁纳米颗粒,通过对反应条件的控制观察对合成零价纳米铁颗粒形貌的影响,并利用透射电子显微镜(TEM)、扫描电子显微镜(SEM)、X射线粉末衍射仪(XRD)和傅里叶红外光谱仪(FT-IR)等仪器进行表征。所用螯合剂为FDA批准的医用螯合剂,包括甲磺酸去铁胺和地拉罗司,它们是目前治疗人体铁过载的常用螯合剂。结果:通过对螯合剂含量的控制,结果表明,随着螯合剂量的增加,合成的零价纳米铁颗粒的粒径越来越小。而对比在相同条件下利用螯合剂合成零价纳米铁存在条件下,结果发现,有地拉罗司存在条件下生成的零件铁纳米颗粒粒径要比甲磺酸去铁胺的小。由此可以得出:在相同条件下,地拉罗司螯合Fe3+的能力要强于甲磺酸去铁胺组,故而在合成零价纳米铁过程中,地拉罗司的存在有助于合成粒径更小的纳米颗粒,同时合成的纳米颗粒在空气中稳定存在,不易被氧化,整个合成过程也不需要通入氮气,反应条件比较温和。结论:利用甲磺酸去铁胺和地拉罗司螯合剂能够合成稳定的零价纳米铁颗粒,并能够通过对螯合剂含量和其他反应条件的控制,达到对零价铁纳米颗粒粒径可控的目的。相对于甲磺酸去铁胺来说,地拉罗司制备的零价纳米铁颗粒粒径更小。更多还原

【Abstract】 Objective:To synthesize stable Zero valent iron nanoparticle（NZVI） and dicuss the change of morphology of NZVI by controlling the Reaction Conditions.Methods:Based on the Liquid phase synthesis method,NZVI has been synthesized with different chelating agents.In aqueous solution or ethanol-aqueous solution,I use Sodium borohydride to reduce Ferric ion to zero-valent iron and then synthesize NZVI.I discuss the change of Morphology of NZVI by controlling the Reaction Conditions.At the same time,I characterize the different NZVI by TEM,SEM,XRD and FT-IR.Deferoxamine and Deferasirox are the Chelating agents which I use to help to synthesize air stable NZVI.They are common drugs which are used for the treatment of Iron overload in clinic.Of course,they are also these drugs which have acquired the approval of FDA.Results:Stable Zero Valent Iron Nanoparticle has been synthesized,the size of nanoparticle can be controlled by changing Reaction Conditions,including the density of Ferric ion,Nature of the solvent,Chelating agent quality accounts for the proportion of the total quality of Chelating agent and FeCl₃·6 H₂O etc.Compared to Deferoxamine,it is better to synthesize smaller-size zero valent iron nanoparticle when the equal quality propotion of Deferasirox exists.So Deferasirox is a good choice if we want to synthesize smaller-size air stable NZVI.Conclusion:It’s feasible to synthesize stable Zero Valent Iron nanoparticle with Chelating Agents.By changing Reaction Conditions,the size of nannoparticle can be controlled.更多还原