【作者】 李绍炜； 刘嗣源； 李自发； 张浩； 耿希文； 魏盛；

【Author】 LI shaowei;LIU siyuan;LI zifa;ZHANG hao;GENG xiwen;WEI sheng;Innovative Institute of Chinese Medicine and Pharmacy,Shandong University of Traditional Chinese Medicine;Experimental Center,Shandong University of Traditional Chinese Medicine;

【机构】 山东中医药大学中医药创新研究院； 山东中医药大学实验中心；

【摘要】 化学遗传操控技术的出现彻底改变了抑郁症神经环路的研究,展现出对细胞活性的强大控制能力,能精确有效地操纵神经元活动。化学遗传操控技术通过受体的设计,利用特定药物激活设计受体来调节神经细胞活性,从而对不同类型的神经元和相关环路进行特异性调控。与传统药理学手段相比,其可以增强细胞类型的时空调控,更精确的解析抑郁症背后的神经环路。在这篇综述中,我们从慢性社会挫败应激模型、慢性不可预见应激模型、慢性温和应激模型等动物模型入手,探讨化学遗传操控技术在抑郁症神经环路中的发展与应用,阐明了相关脑区对于抑郁症的影响如腹侧被盖区、伏隔核、内侧前额叶皮质、腹侧海马等,讨论了化学遗传操控技术作为一种精准调节神经的技术在抑郁症机制研究中的潜力和挑战。更多还原

【Abstract】 The emergence of chemogenetic has revolutionized the study of neural circuits in depression,demonstrating a strong ability to control cell activity and accurately and effectively manipulate neuronal activity.chemogenetic regulates the activity of nerve cells through the design of receptors,using specific drugs to activate and design receptors,thereby specifically regulating different types of neurons and related circuits.Compared with traditional pharmacological methods,it can enhance the spatiotemporal regulation of cell types and more accurately analyze the neural circuitry behind depression.In this review,we begin with animal models such as chronic social frustration stress model,chronic unpredictable stress model,and chronic mild stress model to explore the development and application of chemical genetic manipulation techniques in the neural circuitry of depression,and clarify the effects of relevant brain regions on depression,such as the ventral tegmental area,nucleus accumbens,medial prefrontal cortex,and ventral hippocampus,The potential and challenges of chemical genetic manipulation as a technique for precise neural regulation in the study of depression mechanisms were discussed.更多还原