【作者】 张学敏； 王锦锦； 李稳静； 王书； 张颖； 吴泽兵； 胡世莲；

【Author】 Zhang Xuemin;Wang Jinjin;Li Wenjing;Wang Shu;Zhang Ying;Wu Zebing;Hu Shilian;Department of geriatrics,The Third Affiliated Hospital of Anhui Medical University,The First People’s Hospital of Hefei;The First Affiliated Hospital of USTC,Division of Life Sciences and Medicine,University of Science and Technology of China;Gerontology Institute of Anhui Province;Anhui Provincial Key Laboratory of Tumor Immunotherapy and Nutrition Therapy;

【机构】 安徽医科大学第三附属医院(合肥市第一人民医院)老年病科； 中国科学技术大学附属第一医院(安徽省立医院)； 安徽省老年医学研究所； 肿瘤免疫与营养治疗安徽省重点实验室；

【摘要】 目的分析老年高血压患者血压变异性(BPV)与血管紧张素(1-7)[Ang(1-7)]的变化及两者之间的关系。方法选取我院门诊2、3级老年高血压患者52例为高血压组,体检血压正常的老年人50例入选为对照组,入选病人均检测血脂、空腹血糖、血尿酸,ELISA法检测血浆Ang(1-7)水平,监测24小时动态血压。结果:1.对照组、高血压组患者在性别、年龄、吸烟、TG、TC、LDL-C、HDL-C、FPG、UA、诊室收缩压、诊室舒张压差异均无统计学意义(P>0.05)。2.对照组与高血压组的24hSBP、24hDBP、dSBP、dDBP、nSBP、nDBP差异均无统计学意义(P>0.05)。3.对照组与高血压组的24hSBPV、24hDBPV、dSBPV、dDBPV、nSBPV差异均有统计学意义(P<0.05)。4.对照组与高血压组血管紧张素(1-7)差异有统计学意义(P<0.01)。5.对照组与高血压组的Ang-(1-7)与24hSBPV均有相关性,与24hDBPV、dSBPV、dDBPV、nSBPV、nDBPV无相关性(P均>0.05)。结论:老年高血压患者血压变异性增大、血管紧张素(1-7)水平减低,而且Ang(1-7)的水平降低与24h SBPV升高密切相关。更多还原

【Abstract】 objective To analyze the changes of blood pressure variability(BPV) andangiotensin(1-7)[Ang(1-7)]in elderly patients with hypertension and the relationship between them.MethodsTo collect the hospital outpatient grade 2,3,a total of 52 patients with high blood pressure as the hypertensive group,physical examination of normal elderly patients with 50 cases as control group,respectively the BPV of two groups of patients with observed,angiotensin(1-7),the average blood pressure,total cholesterol,triglyceride,low density lipoprotein cholesterol(ldl-c),high-density lipoprotein cholesterol(hdl-c),fasting blood glucose,blood uric acid value.Results 1.There were no statistically significant differences in gender,age,smoking,TG,TC,ldl-c,hdl-c,FPG,UA and blood pressure in the clinic between the control group and the hypertensive group(P>0.05).2.There were no statistically significant differences between the control group and the hypertensive group in 24 hSBP,24 hDBP, dSBP,dDBP,nSBP and nDBP(P>0.05).3.There were statistically significant differences between the two groups at 24 hSBPV, 24 hDBPV,dSBPV,dDBPV,nSBPV(P<0.01).4.There were statistically significant differences in angiotensin(1-7) between the two groups(P<0.01).In the two groups,angiotensin(1-7) was correlated with 24 hSBPV,but not correlated with 24 hDBPV,dDBPV,nSBPV,nDBPV(all P>0.05).Conclusion in elderly patients with hypertension,the blood pressure variability increases and the level of angiotensin(1-7)decreases,while the decrease of angiotensin(1-7) can lead to the increase of SBPV and dSBPV at 24 h.There were significant correlation between blood pressure variability andangiotensin(1-7) in eldly patients with hypertension.更多还原