体外诱导蜕膜样NK细胞促进胚胎发育（英文）

【作者】 杜祥慧； 傅斌清； 矫德峰； 粘志刚； 张璟鹤； 周永刚； 郑小虎； 魏海明；

【机构】 中国科学技术大学生命科学与医学部； 中国科学技术大学免疫所； 中国科学技术大学合肥微尺度物质科学国家研究中心；

【摘要】 Recent studies have shown that the recurrent spontaneous abortion(RSA) may mainly related to abnormal immune microenvironment at the maternal-fetal interface during pregnancy,especially abnormal decidual natural killer cells(d NKs).In order to establish an effective treatment for RSA,an amplification system of induced human decidual-like NK cells(id NKs) based on cytokine without feeder-cell in vitro was established.Id NKs have similar phenotypes and functions with d NKs,including high expression of CD49 a and low expression of CD16 and cytotoxic capability.Furthermore,the idNK cells also had high expression of growth-promoting factors(GPF s),which were very important for promoting fetal development during early pregnancy.In the future,this research of inducing decidual-like GPF-secreting NK cells in a human system may improve the feasibility of applying these decidual-like NK cells to the RSA patients and give rise to achieve healthy reproduction.更多还原

【Abstract】 Recent studies have shown that the recurrent spontaneous abortion(RSA) may mainly related to abnormal immune microenvironment at the maternal-fetal interface during pregnancy,especially abnormal decidual natural killer cells(d NKs).In order to establish an effective treatment for RSA,an amplification system of induced human decidual-like NK cells(id NKs) based on cytokine without feeder-cell in vitro was established.Id NKs have similar phenotypes and functions with d NKs,including high expression of CD49 a and low expression of CD16 and cytotoxic capability.Furthermore,the idNK cells also had high expression of growth-promoting factors(GPF s),which were very important for promoting fetal development during early pregnancy.In the future,this research of inducing decidual-like GPF-secreting NK cells in a human system may improve the feasibility of applying these decidual-like NK cells to the RSA patients and give rise to achieve healthy reproduction.更多还原