【作者】 薛慧敏； 费进波； 李峻柏；

【Author】 Huimin Xue;Jinbo Fei;Junbai Li;Institute of Chemistry,Chinese Academy of Sciences;

【机构】 胶体界面与化学热力学院重点实验室中国科学院化学研究所；

【摘要】 以活性马达蛋白分子为构筑基元,构建多层次结构的仿生组装体,是模拟或调控生命重要过程的有效途径之一。三磷酸腺苷(ATP)是自然界绝大多数生命体的能量"货币",主要在细胞能量工厂中通过跨膜质子梯度势驱动生物马达蛋白分子ATP合成酶旋转催化合成。近年来,我们有效整合分子组装技术与功能纳米材料制备技术,通过重组ATP合酶与纳米酶,通过构筑"人工-自然"杂化多级结构系统,模拟了线粒体的氧化磷酸化过程,实现了高效的无细胞合成ATP [1]。更多还原

【Abstract】 Active motor proteins have been utilized as building blocks to fabricate biomimetic systems to simulate or regulate important processes in living organisms. Adenosine triphosphate(ATP) is the energy "currency" of most living organisms in nature, mainly synthesized through motor protein ATP synthase catalysis driven by the transmembrane proton gradient in the cellular energy plants. We have effectively integrated molecular assembly technology and functional nanomaterial preparation technology, and through the construction of "artificial-natural" hybrid hierarchically structured system by recombining ATP synthase and nanozyme, high-efficiency cell-free synthesis of ATP has been achieved.更多还原