【作者】 李娜； 唐波；

【Author】 Na Li;Bo Tang;College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Normal University;

【机构】 山东师范大学化学化工与材料科学学院分子与纳米探针教育部重点实验室；

【摘要】 恶性肿瘤(癌症),是当今严重威胁人类健康的主要疾病之一,防治癌症的关键在于早期诊断和有效治疗。纳米粒子具有独特的四大效应以及声、光、电、热和磁等特性,利用这些特性,通过优化材料可以构建稳定、高效和安全的纳米探针,用于肿瘤的精准诊断及高效治疗。基于此,我们设计了多种用于癌症诊疗的功能纳米材料:设计合成了双模式探针,实现了对肿瘤相关mRNA的荧光/光声双模式比率检测;设计了一种基于α环糊精的金/DNA纳米机器,用于肿瘤微环境触发的光声诊断和光热治疗;首次研究了利用光敏剂产生活性氧触发线粒体内活性氧爆发的肿瘤光动力学治疗模式;首次将双光敏剂靶向进入细胞核内,实现了在细胞核内产生大量活性氧对多药抗药性肿瘤进行高效光动力学治疗。更多还原

【Abstract】 Malignant tumors(cancers) have been a serious threat to human health, and successful cure of most cancers depends on early detection and timely treatment. Nanoparticles have four big nanometer effects and unique properties including acoustic, optical, electrical, thermal, and magnetic properties. By taking advantages of these properties, we can optimize the materials to construct stable, efficient, and safe nanoprobe for precise tumor diagnosis and efficient therapy. Based on this point, we have designed and synthesized a variety of nanomaterials for cancer diagnosis and treatment. We have developed a dual-mode DNA nanoprobe for fluorescence imaging and photoacoustic imaging of tumor-related mRNA. A theranostic gold nanomachine constructed from α-cyclodextrin-based gold/DNA has been successfully developed for tumor-selective photoacoustic imaging and photothermal therapy. For the first time, we have demonstrated that the photodynamic cancer therapy could be achieved by using a photosensitizer to induce mitochondrial ROS burst. We have firstly designed and fabricated a nuclear targeted dual-photosensitizer for photodynamic therapy against multidrug resistant cancer.更多还原