【作者】 袁肇凯； 黄献平； 张月娟； 孙安会； 夏世靖； 简维雄； 孙贵香； 王丽萍；

【Author】 Yuan Zhao-kai;Huang Xian-ping;Zhang Yuejuan;Hunan University of TCM;

【机构】 湖南中医药大学；

【摘要】 目的:探讨冠心病血瘀证的遗传特征。方法:运用"病例对照"的遗传流行病学家系调查方法,对冠心病血瘀证家系(为观察组)1565人和冠心病非血瘀证家系(为对照组)1553人进行分离比、遗传度、遗传模式及多基因遗传方式等遗传参数进行计算分析。结果:①观察组亲属冠心病血瘀证的患病率(5.24%)显著高于对照组(1.29%)均P <0.05。②观察组一级亲属分离比为0.1296,明显低于盂德尔单基因遗传病的分离比(0.25),符合多基因遗传病的特点。③冠心病血瘀证一级亲属遗传度为58.04%,二级亲属遗传度为54.80%,均低于60%,属中度遗传。④观察组一级亲属遗传度为0.5804时,其理论发病率为8.00%,与实际发病率5.89%呈接近趋势;二级亲属的遗传度为0.5480时,其理论发病率为6.20%,与实际发病率4.13%呈接近趋势。结论:冠心病血瘀证具有一定的家族聚集的倾向,冠心病血瘀证在家系中的分布符合多基因遗传的特征。更多还原

【Abstract】 Objective:to explore the Hereditary characteristics of Blood-Stasis Syndrome of Coronary Heart Disease.Methods:1565 patients of Blood-Stasis Syndrome of Coronary Heart Disease family(observational group) and 1553 patients of non Blood-Stasis Syndrome of Coronary Heart Disease family(controlled group) were included in our study,we have taken analysis of segregation ratio,heredity grade,hereditary model and polygene mode of inheritance by "case-controlled" hereditary epidemiological genealogy investigation method.Results:①the morbidity of Coronary Heart Disease of the relatives in observtional goup(5.24%) is significantly higher than the controlled group(1.29%)(P<0.05).②the segregation ratio of the first degree relative is 0.1296,that significantly lower than the segregation ratio of the Mendel monogene hereditary disease(0.25),which in accord with the characteristics of polygene hereditary disease.③the heredity grade of the first and second degree relative of Blood-Stasis Syndrome of Coronary Heart Disease is 58.04% and 54.80%,both of them is lower 60%,which is belong to moderate heredity.④when the heredity grade of the first degree relative in the observational group is 0.5804,the theoretical morbidity is8.00%,which is near to the actual morbidity(5.89%);when the heredity grade of the second degree relative is0.5480,the theoretical morbidity is 6.20%,which is near to the actual morbidity(4.13%).Conclusion:the Blood-Stasis Syndrome of Coronary Heart Disease exhibit familial aggregation tendency to some extent,the genealogy distribution of the Blood-Stasis Syndrome of Coronary Heart Disease is accord with the characteristics of the polygene heredity.更多还原