Multifunctional peptides-hydroxyapatite hybrid nanoparticles for metastatic cancer combination therapy

【作者】 Hui Xiong； 姚静；

【Author】 Hui Xiong;Jing Yao;State Key Laborary of Natural Medicine and Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, Department of Pharmaceutics, China Pharmaceutical University;

【机构】 State Key Laborary of Natural Medicine and Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, Department of Pharmaceutics, China Pharmaceutical University；

【摘要】 <正>The hybrid nanomaterials based on"hetero-supramolecular"ideas facilitated the development of organicinorganic hybrid materials through providing a way of bridging the gap between molecular chemistry,materials sciences,and nanotechnology.In our study,multifunctional combination peptide sequence(MCPS)composed of tumor nest and pre-metastatic niches dual-targeting peptide(CREKA),mitochondria damage更多还原