【作者】 高宁； 尹先鹏； 梁云； 董浩； 李广涛；

【Author】 N.Gao;X.P.Yin;Y.Liang;H.Dong;G.T.Li;Key Lab of Organic Optoelectronics and Molecular Engineering,Department of Chemistry,Tsinghua University;

【机构】 清华大学； 清华大学化学系有机光电子与分子工程教育部重点实验室；

【摘要】 我们发展了一种通过微流控组装手段来高效制备水凝胶微球的新方法,水凝胶微球中的活性腔室可以作为优势平台来灵活构建具有时空功能可控的多孔多腔室微球体系。这种制备多腔室微球体系的方法不仅可以迅速高效的获得尺寸和孔结构可调的水凝胶微球,而且可以通过模块化的方式将不同的亚腔室引入其中。另外,多腔室中不同亚腔室的种类、数目以及比例可以按照需求灵活调节。更为重要的是,通过正交反应,不同功能的活性单元可以被进一步接枝到不同的亚腔室中,以此来得到功能上精心设计的多腔室体系。我们发展的这种高效的新策略为构建具有高度灵活性和可拓展性的功能性多腔室体系开拓了新思路。更多还原

【Abstract】 A microfluidic assembly approach was developed for efficiently producing hydrogel spheres with reactive multidomains that can be employed as an advantageous platform to create spherical porous networks in a facile manner with welldefined multicompartments and spatiotemporally controlled functions.This strategy allows for not only large scale fabrication of various robust hydrogel microspheres with controlled size and porosity,but also the domains embedded in hydrogel network could be introduced in a modular manner.Additionally,the number of different domains and their ratio could be widely variable on demand.More importantly,the reactive groups distributed in individual domains could be used as anchor sites to further incorporate functional units in an orthogonal fashion,leading to well-defined multicompartment systems.The strategy provides a new and efficient route to construct well-defined functional multicompartment systems with great flexibility and extendibility.更多还原