【作者】 雷鹏； 张学博； 张小河； 徐焱； 杨新玲； 张晓鸣； 凌云；

【Author】 LEI Peng;ZHANG Xue-bo;ZHANG Xiao-he;XU Yan;YANG Xin-ling;ZHANG Xiao-ming;LING Yun;Key Laboratory of Pesticide Chemistry and Application,Ministry of Agriculture,Department of Applied Chemistry,College of Science,China Agricultural University;

【机构】 中国农业大学理学院应用化学系农业部农药化学及应用重点开放实验室；

【摘要】 [目的]本文在前期工作基础上,进行深入研究,合成了一系列含1,2,3,4-四氢喹啉结构的吡唑-5-甲酰胺类化合物,以期发现具有高杀菌活性的先导化合物。[方法]以取代酮为起始原料,经5步反应进行目标物的合成,并进行了初步杀菌活性评价。[结果]合成了10个目标化合物,结构均经~1HNMR和IR分析确证。[结论]生测结果表明,目标化合物具有一定的离体杀菌活性,其中化合物7h和7j效果较好,具有作为先导进一步研究的价值。更多还原

【Abstract】 [Aims]To find new lead compound with high biological activity,a series of pyrazole-5-carboxamide derivatives containing 1,2,3,4-tetrahydroquinoline were synthesized based on our previous studies.[Methods]The target compounds were synthesized from substituted ketone in 5 steps and their fungicidal effects were preliminarily evaluated.[Results]10 title compounds were obtained and their structures were confirmed by ~1H NMR spectra and IR spectrum.[Conclusions]The in vitro bioassay results indicated that synthesized target compounds exhibit certain fungicidal activities.Compound 7h and 7j,exhibited satisfied fungicidal activities at a concentration of 50 μg/mL,could be valuable for further study.更多还原