【作者】 杨鹤超； 钱明； Mehari Gebre-Medhin； 阎玉芹； 陈祖培；

【Author】 Hechao Yang;Ming Qian;Mehari Gebre-Medhin;Yuqin Yan;Zupei Chen;Department of Clinical Psychology,Tianjin Huanhu Hosipital;Department of Medical Psychology,Tianjin Medical University;Department of Women’s and Children’s Health,Uppsala University;Research Institute of Endocrinology,Tianjin Medical University;

【机构】 天津市环湖医院心理科； 天津医科大学医学心理学教研室； Department of Women’s and Children’s Health,Uppsala University； 天津医科大学内分泌研究所；

【摘要】 目的:目前,母亲妊娠期甲状腺功能状况对后代神经智力发育影响的研究成为学界热点。本文旨在探讨母亲在妊娠各期亚临床甲状腺功能不足(包括亚临床甲状腺功能减退症、单纯低游离甲状腺素血症)对其子女脑发育的影响。方法:选取新疆阿克苏地区拜城、乌什2县妊娠妇女为研究对象。将其分为亚甲减组、低FT4血症组和对照组,并对她们的子女进行DDST发育筛查。运用SPSS 11.5进行统计分析,以P<0.05为差异有统计学意义。结果:妊娠早中期亚甲减组母亲的子女生后DDST迟缓率(31.2%)高于对照组(13.5%),差异有统计学意义(P=0.049)。妊娠中期DDST迟缓组母亲血清TSH水平(M=2.58 mIU/L)高于对照组(M=2.29 mIU/L),差异有统计学意义(P=0.029)。结论:妊娠早中期母亲亚临床甲状腺功能减退可能与其后代脑发育迟缓有关,妊娠中期母亲血清TSH水平升高对后代脑发育迟缓可能更有预测价值。更多还原

【Abstract】 Objective: Recently, more and more attention have been paid to the impact of maternal thyroid hormones on neuropsychological development of their offsprings. We explore the impact of maternal subclinical thyroid dysfunction among gestration on brain development of offsprings, which involve in subclinical hypothyroidism and hypothyroxinemia. Method: Pregnant women who live at BAICHENG and WUSHI in Aksu of XINJIANG were selected. The groups of subclinical hypothyroidism and hypothyroxinemia were studied compared with the control group. And the offsprings of the pregnancy were administrated with DDST. And the statistc software is SPSS11.5. We use 0.05 as the cut-point of significance. Result: In the first two trimesters, delay ratio of infants whose mothers belong to subclinical hypothyroidism group（31.2%） is significantly higher than that of control group（13.5%）（P=0.049）. In 2^nd trimester, the median concentration of maternal TSH of delay group（M=2.58 mIU/L） is significantly higher than that of control group（M=2.29 mIU/L）. Conclusion: Maternal subclinical hypothyroidism in the first two trimesters maybe associated with mental development of offsprings. The increasing concentration of TSH is probably valubal to predict the possibility of mental development retardation.更多还原