【作者】 谢孟峡；

【Author】 Mengxia Xie;Analytical & Testing Center, Beijing Normal University;

【机构】 北京师范大学分析测试中心；

【摘要】 色谱-质谱联用技术具有灵敏度高,分离能力强,可同时对分析物进行定性和定量检测等特征,特别是与样品预处理技术相结合,在复杂基质中痕量残留物的分析中具有独特的优势。对于复杂基质样品,在质谱分析前,通常需要对分析物进行净化和富集。对分析物进行衍生化,可以有效的改变分析物的性质,提高其挥发性,使其能够用气相色谱-质谱进行分析。如对乳化炸药爆炸残留物分析时,可以通过对乳化剂中山梨醇的衍生化,获取其气相色谱-质谱特征指纹谱带,从而实现对该乳化炸药的溯源分析。分子印迹材料在样品的净化和富集方面具有选择性好,特异性强的优点,我们合成了塑化剂的模拟模板分子,并制备了以该化合物为模板的表面分子印迹材料,从而建立了饮料中9种塑化剂的气相色谱-质谱分析方法。基体固相扩散技术具有样品用量少,可集萃取与净化过程为一体的优点,我们采用该技术对肉食品的激素进行净化和富集,并建立了激素的高效液相色谱-质谱分析方法。更多还原

【Abstract】 The chromatography-mass spectrometry technique has high sensitivity and strong separation ability,and it can qualitatively and quantitatively detect the analytes,therefore,it possesses the unique advantage for determination of the trace residues in complex matrix when coupling with sample pretreatment procedures.The samples of complex matrix usually should be purified and enriched prior to analysis of mass spectrometry.For the postblast residues of the emulsion explosives,the sorbitols in the emulsifier were derivatized by silylation reaction,and the derivatives can be analyzed by GC-MS,then,the information of the characteristic components can help probe the origin of the emulsion explosives.Dummy template molecularly imprinted polymers on silica gel particles for simultaneously selective recognition of nine phthalate esters have been prepared.The approach for simultaneous determination of ten steroid hormones in animal origin food by matrix solid-phase dispersion and liquid chromatography-electrospray tandem mass spectrometry has been established.更多还原