【作者】 苏孝鹏； 胡智文； 刘建军； 王秉；

【Author】 Xiaopeng Su;Zhiwen Hu;Jianjun Liu;Wang Bing;College of Materials and Textiles, Zhejiang Sci-Tec University;

【机构】 浙江理工大学材料与纺织学院；

【摘要】 石墨烯/二氧化钛纳米复合材料具有优良的物理和化学性能,是一种优异的光催化降解催化剂和优良的药物载体,在生物技术和生物医学领域有很好的应用前景。然而对石墨烯/二氧化钛纳米复合材料的细胞毒性研究是十分重要的。在本报道中,我们通过水热法制备了二氧化钛纳米管和石墨烯/二氧化钛纳米复合材料,然后通过与RAW264.7小鼠巨噬细胞相互作用研究其细胞毒性,对细胞形貌、活性的影响。研究发现在与石墨烯/二氧化钛经过48小时的共同培养后,RAW264.7细胞的存活率仍然保持在90%以上并且具备良好的粘附、迁移性能,说明石墨烯/二氧化钛纳米复合材料具有低的细胞毒性和高的生物相容性。更多还原

【Abstract】 rGO/TNT nanocomposites is believed to be promising in the area of bionanotechnology and nanobiomedicine, which exhibit great chemical and physical properties, is an excellent photocatalytic catalyst and an ideal nanocarriers for drug delivery. However, it’s important to study the cell cytotoxicity of the rGO/TNT nanocomposites before it be widely used. In this study, we successfully synthesized rGO/TNT nanocomposites through a modified hydrothermal treatment method. RAW264.7 cells were used to study the interactions between rGO/TNT nanocomposites and cells, such as the regulation of cell morphology, cell cytotoxicity etc. After incubation with rGO/TNT nanocomposites for 48 h, the cell viability still kept above 90%, the cell adhesion ability and cell migration ability was excellent. These findings indicated that the promising rGO/TNT nanocomposites have low cytotoxicity and high biocompatibility.更多还原