【作者】 张芳； 韩丽； 张定堃； 秦春凤；

【Author】 ZHANG Fang;HAN Li;ZHANG Ding-kun;QIN Chun-feng;Chengdu University of Traditional Chinese Medicine Key Laboratory of System Research and Development of Traditional Chinese Medicine Resources;

【机构】 成都中医药大学中药资源系统研究与开发利用省部共建国家重点实验室培育基地；

【摘要】 对微粉硅胶的粉体学性质进行了归纳,并对制备工艺、表面改性、干燥工艺等影响粉体学性质的因素加以分析;对多种结构的介孑L二氧化硅及微粉硅胶的促崩解、助悬、促吸收等新用途进行了介绍。虽然微粉硅胶用于药物输送系统已有较多报道,但目前的研究都只局限于一些药物在动物细胞中的传递,在将来的实际应用中仍有许多问题需要解决,如体内代谢、急性和长期毒性、长期稳定性、循环性能等,特别是药物载药系统在体内的详细过程及毒理学研究,将微粉硅胶用于临床之前还要进行长期实验研究。更多还原

【Abstract】 The micro-silica gel show a good prospect in new applications and new drug carriers for its unique microstructure.Initially,the micromeritic properties of micro-silica gel are summarized,the affecting factors of the micromeritic properties including preparation process,surface,modification and drying process are analyzed.Then,mesoporous silica in a variety of structures and new applications of promoting disintegration,suspending,and strengthening absorption are reviewed in order to promote the application and development of the micro-silica gel in pharmaceutics.更多还原