【作者】 刘若轩； 李丽明； 吴菲； 李阿荣； 刘夏雯； 郭洁文；

【Author】 LIU Ruo-xuan;LI Li-ming;WU-Fei;LI A-rong;LIU Xia-wen;GUO Jie-wen;Department of Pharmacy,Guangzhou Hospital of Traditional Chinese Medicine;Guangzhou University of Chinese Medicine;affiliated Guangzhou Hospital of Traditional Chinese Medicine of Guangzhou University of Traditional Chinese Medicine;The Pharmaceutical Research Center of Guangzhou Medical University;

【机构】 广州市中医医院药学部； 广州中医药大学； 广州中医药大学附属广州中医院； 广州医科大学药物研究中心；

【摘要】 目的:研究以不同给药方式给予大鼠马钱子碱脂质体后,马钱子碱在大鼠体内的药动学规律和差异。方法:马钱子碱脂质体经口服（po）、肌肉注射（im）、皮下注射（ih）、静脉注射（iv）后,采用高效液相色谱法测定不同时间点大鼠血浆中马钱子碱的浓度,并用DAS 3.0拟合房室模型,计算药动参数。结果:不同给药方式比较,ih组AUC_0-t高于其他组,C_max低于其他组,MRT_0-t显著高于其他组。结论:药动学参数及绝对生物利用度表明,马钱子碱脂质体不同给药方式的体内生物利用度为ih>im>po。更多还原

【Abstract】 Objective:To compare the pharmacokinetic differences of brucine in rats after different administration methods of brucine liposome. Method:To determine brucine in rat plasma at different points in time by HPLC after oral administration（po）, intramuscular injection（im）, subcutaneous injection（ih）, intravenous injection（iv） of brucine liposome respectively. The pharmacokinetic parameters were calculated and analyzed by DAS 3.0. Result:Compared with other groups, AUC_0-t of ih were higher, C_max were lower and MRT_0-t were significantly improved. The pharmacokinetics parameters and absolute bioavailability of brucine shows that bioavailability in rats after different administration methods of brucine liposome is ih>im>po.更多还原