【作者】 唐秀娟； 房师松； 吕星；

【Author】 TANG Xiu-juan;FANG Shi-song;LU Xing;Shenzhen Center for Disease Control and Prevention;

【机构】 深圳市疾病预防控制中心；

【摘要】 目的 2013年H7N9禽流感病毒在我国很多省份导致了暴发疫情,多数为重症肺炎病例,也有少数轻症病例报道,但隐形感染者的情况并不清楚,本研究对深圳市活禽市场工作人员的H7N9禽流感病毒抗体水平进行调查,对感染的危险因素进行研究。方法 2013年12月在深圳市7个区的活禽市场对市场经营人员进行问卷调查,采集血样,用血凝抑制试验进行H7N9禽流感病毒抗体的检测,用多因素logistic回归模型对H7N9病毒感染的危险因素进行分析。结果本次调查共选取了250名活禽市场人员进行问卷调查和血样采集,男性141人,女性109人,年龄中位数为41岁,血凝抑制试验结果显示38人(15.2%)的H7N9病毒抗体滴度≥160,为阳性,其中男性和女性均为19人。多因素logistic回归分析结果,接触鸭子为H7N9病毒感染的高危因素(OR=3.85,P<0.01),活禽暴露时间,暴露方式和流感疫苗接种等因素对H7N9病毒感染的影响没有显著性。结论在活禽市场人员中检测出相对较高的H7N9病毒抗体水平,说明高危人群中存在这一定数量的隐形感染者,H7N9病毒感染的高危因素还需进一步研究。更多还原

【Abstract】 Objective The novel influenza A H7 N9 virus emerged in China in 2013,it has been speculated that there are much more asymptomatic patients who were infected with H7 N9 virus and had not been reported. We aimed to examine the seroprevalence to H7 N9 virus among poultry workers in Shenzhen and identify related risk factors. Methods The serological survey of poultry market workers was conducted in December of 2013,Subjects were recruited in poultry markets across 7 districts of Shenzhen. Blood samples were taken for detecting antibody to novel influenza A H7 N9 virus by using hemagglutination-inhibition test. Multivariate analysis was employed to identify risk factors related to H7 N9 infection.Results 250 subjects were recruited for serological survey with age median of 41,including 141 male and 109 female. 38(15.2%) poultry workers had HI antibody titer≥160 to novel influenza A H7 N9 virus,including 19 male and 19 female. In the multivariate analysis,exposure to duck(OR 3.85,P<0.01)was identified as the risk factors for seropositivty to novel influenza A H7 N9 virus,and other factors such as length of exposure to poultry,way of exposure and seasonal influenza vaccination were not identified affecting H7 N9 infection significantly. Conclusions The comparatively high seropositivity to novel influenza A H7 N9 virus among poultry workers suggested that there were more asymptomatic patients than laboratory-confirmed cases in Shenzhen. Study on risk factor of H7 N9 infection should be carried out further in the future.更多还原