【作者】 张凤莉； 祁清凯； 徐斌； 田文晶；

【Author】 Fengli Zhang;Qingkai Qi;Bin Xu;Wenjing Tian;State Key Laboratory of Supramolecular Structure and Materials,Jilin University;

【机构】 超分子结构与材料国家重点实验室化学学院吉林大学；

【摘要】 近红外荧光分子由于具有较长的吸收波长和能够避免组织自体荧光干扰的特点,因此具有较深的组织渗透能力和较高的图像敏感度,在光学成像领域得到了广泛的关注。我们通过在四苯基乙烯分子上连接电子给体（N（CH₃）₂）和电子受体（-CN）合成了一系类具有聚集诱导发光（AIE）性质的高效率的近红外荧光分子。通过双亲聚合物F-127包覆荧光分子制备了均一稳定的纳米粒子,并用于癌细胞成像。结果表明,此类荧光纳米粒子具有低毒性,高光稳定性,高对比度等优点。更多还原

【Abstract】 Organic Fluorescent probes play a key role in modern biomedical research,such as biological sensing and imaging.However,the development of organic fluorophores with efficient aggregated-state emissions expanded into the red to near-infrared region is still challenging.Here,we present a series of far-red/near-infrared(FR/NIR)fluorophores with aggregation-induced emission properties through attaching electron donor and electron accepter to tetraphenylethene(TPE) moieties.These compounds exhibits the pronounced fluorescence enhancement in aggregate state,the red to near infrared emission,and facile fabrication into uniform NPs.The biological imaging studies reveal that they are effective fluorescent probes for cancer cell with high specificity,high photostability and good fluorescence contrast.更多还原