【作者】 刘海玲； 苑春歌； Sumaira Hanif； 王康； 夏兴华；

【Author】 Hai-Ling Liu;Chun-Ge Yuan;Sumaira Hanif;Xing-Hua Xia;Kang Wang;State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University;

【机构】 生命分析化学国家重点实验室,南京大学化学化工学院；

【摘要】 多孔纳米结构已广泛用于生物传感、细胞分析和生物医学等研究领域^[1,2],因此,制备尺寸可控的纳米孔是至关重要的。本文通过二硫醇作为连接分子在纳米毛细管尖端自组装AuNPs,从而形成尺寸可控的纳米球体多孔结构（如Fig.1所示）。该组装体的孔隙大小可通过连接分子的长度进行调节,其光/电性能呈现出相应的变化规律。基于AuNPs间大量的"热点"存在,此多孔结构具有很强的拉曼增强和整流效应,故可将其作为光/电信号的增强基底,从而发展能够从细胞微区中直接获得生物分子的光谱与电化学等多元信息的分析新方法。更多还原

【Abstract】 Nanoporous structures have been widely demonstrated in biosensing, cell analysis and biomedical study, for which uniform and size controllable nanopores with special features are highly desirable. Herein, we are reporting precisely controlled self-assembly of AuNPs to form gold nanoporous spherical structure(GPSS) by using dithiol alkane as linker on the tip of a glass capillary. Multiple pore sizes with high controllability are fabricated by using different linker molecules, respectively. The GPSS exhibit very stable ion current rectification and SERS effects due to the presence of nanopores with numerous "hot spots" among the AuNPs. Therefore, it can be used as an optical/electrical signal enhancement substrate to directly obtain the spectrum and electrochemical information of biological molecules from the cell micro zone.更多还原