【作者】 徐晓冬； 周慧云； 常秀娟； 李春明； 周建； 邱蕾蕾； 李昕； 石强； 栾世方； 金晶； 殷敬华；

【Author】 XU Xiaodong;ZHOU Huiyun;CHANG Xiujuan;LI Chunming;ZHOU Jian;QIU Leilei;LI Xin;SHI Qiang;LUAN Shifang;JIN Jing;YIN Jinghua;Polymer Materials Research Center,Key Laboratory of Superlight Materials and Surface Technology,Ministry of Education,College of Materials Science and Chemical Engineering,Harbin Engineering University;State Key Laboratory of Polymer Physics and Chemistry,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences;

【机构】 哈尔滨工程大学,材料科学与化学工程学院,超轻材料与表面技术教育部重点实验室,高分子材料研究中心； 中国科学院长春应用化学研究所,高分子物理与化学国家重点实验室；

【摘要】 <正>聚丙烯具有力学性能优异、易于加工成型、来源丰富、价格低廉、生物稳定性高且无毒等特点,成为五大通用塑料中增长速度最快的品种,同时使其成为开发血液存储与输注用品的首选材料。然而聚丙烯分子自身的非极性,使其表面能低、亲水性差,与血液接触后会发生凝血、溶血,形成血栓,因此提高聚丙烯的生物相容性,特别是血液相容性成为开发聚丙烯血液存储与输注材料的关键。本文首先合成了新型手性接枝单体(S)-1-丙烯酰吡咯烷-2-羧酸更多还原

【Abstract】 Polypropylene(PP) is one of the most commonly used materials in medical apparatus and instruments,owing to its outstanding mechanical properties,non-toxic and low cost.However,because of a lack of polar functional groups along the polymer backbone,PP exhibits poor biocompatibility,which limits its potential application in biomedical field.Graft copolymerization with polar monomers offers an effective approach to introduce polar functional groups on the inert PP backbone and thus introduce some desirable properties for PP.In this study,functionahzation of PP with a chiral monomer containing amino acid residue,(S)-l-acrylyl-pyrrolidine-2-carboxylic acid((S)-APCA),by solid-phase grafting was reported.The grafting degree of PP-g-APCA was determined by chemical titration method and the chemical structure was investigated by Fourier transform infrared spectroscopy(FTIR) and FTIR imaging.The hydrophilicity of PP-g-APCA was tested by static water contact angle and the hemocompatibility of PP-g-APCA was evaluated by protein adsorption and platelet adhesion.更多还原