【作者】 程子泳； 林君；

【Author】 Ziyong Cheng;Jun Lin;State Key Laboratory of Rare Earth Resource Utilization,Changchun Institute of Applied Chemistry,Chinese Academy of Sciences;

【机构】 中国科学院长春应用化学研究所；

【摘要】 新型药物释放系统已成为药学领域的重要发展方向。传统的给药方式,通常药物很快地释放,引起药物浓度在体内迅速地升高,达到峰值后又迅速地下降。这种单调的方式容易过量引起毒副作用或用药不足造成治疗低效。尤其在癌症治疗方面,化疗药物对正常组织通常具有很大的毒副作用,如果能够在时间、空间及剂量上都智能可控的释放药物是人们所期待的。[1]另外,无机纳米粒子具有优异的光电磁性质,能够提供上(下)转换发光、成像、核磁共振造影剂、CT增强及光热转换等优异的功能。因此我们开展了具有多种功能(光、磁性)的无机纳米材料和智能响应性高分子复合材料方面的合成及其在药物装载和控制释放方面的基础研究。[2,3]制备了具有多种尺度与形态的核壳、中空及多孔结构的无机纳米粒子,并通过表面接枝、纳米真空铸造及溶胶-凝胶等方法复合功能性水凝胶,把无机材料优异的光电磁性质与刺激响应的高分子相结合,根据肿瘤疾病的特点探索其化疗药物的智能可控释放。更多还原

【Abstract】 The novel drug delivery system has become the hot topic in research field. The conventional drug release is generally controlled by free diffusion, which leads to a burst or very slow drug release modes. Especially in cancer therapy, the chemotherapeutic drugs are usually very harmful to normal tissues. How to reduce the side effect of the chemotherapeutic drugs is an important issue. Therefore, we prepared the multifunctional nanocomposites based on the stimuli-responsive polymers and inorganic nanoparticles, which are explored to be used as the controlled drug release carriers for chemotherapeutic drugs. Among them, the inorganic component provide the attracting physical properties such as upconverting luminescence or MR imaging contrast, while the stimuli-responsive polymers play a role of regulating the drug release by p H, thermal and et al.更多还原