【作者】 黄鹤； 梁汝萍； 邱建丁；

【Author】 He Huang;Ru-Ping Liang;Jian-Ding Qiu;Department of Chemistry, Nanchang University;

【机构】 南昌大学化学系；

【摘要】 <正>利用性能优越的纳米材料来放大电化学信号从而开发高灵敏度的电化学免疫传感器成为当前的研究热点[1]。石墨烯(GO)是近年来发现的一种具有二维平面结构的碳纳米材料,它的特殊单原子层结构使其具有许多独特的物理化学性质[2]。有关石墨烯的基础及应用研究已成为当前的前沿和热点课题之一,石墨烯更多还原

【Abstract】 A novel electrochemical immunosensor for sensitive detection of cancer biomarker carcinoembryonic antigen(CEA) has been fabricated, which was composed with a graphene sheet sensor platform and Fe3O4/Au NPs hybrid nanoparticles labeled with signal antibodies(Ab2). Greatly enhanced sensitivity for the cancer biomarker has been achieved based on a dual signal amplification strategy. Using the carcinoembryonic antigen as a model analytes, the developed immunoassay method showed linear ranges of 4 orders of magnitude with the detection limit down to 0.39 pg/m L. This amplification strategy provides a promising platform for clinical screening of cancer biomarkers and point-of-care diagnostics.更多还原