【作者】 曹玲娟； 颜苗； 李焕德； 张毕奎； 方平飞；

【机构】 中南大学湘雅二医院药学部； 中南大学临床药学研究所； 中南大学药学院；

【摘要】 雷公藤药理作用广泛,具抗炎、免疫调节、抗肿瘤和抗生育等作用,临床上雷公藤主要用于治疗炎症反应及自身免疫性疾病如风湿关节炎、自身免疫复合性肾炎及系统性红斑狼疮等,但时有毒副反应发生。其毒性反应主要表现在对消化系统、生殖系统和泌尿系统等的损伤,其中肝脏是最主要的毒性靶器官之一,其肝损伤也较严重。目前普遍认为雷公藤所致肝损伤是其含有的多种有毒成分综合作用的结果,损伤机制可能与脂质过氧化反应、细胞凋亡等相关。甘草是最常用的中草药之一,具清热解毒、保肝抗炎和调和诸药等功效,甘草与雷公藤配伍可显著减轻雷公藤所致肝损伤,其减毒作用确切,但作用机制仍缺少深入研究。本文综述了近年来对雷公藤肝损伤及其相关机制的研究,以及雷公藤与甘草及其他中药配伍减毒的研究进展,以期为日后相关研究提供参考。更多还原

【Abstract】 Tripterygium wilfordii Hook.f.(TWHF) has exihibited multiple pharmacological activities,such as anti-inflammatory,immune modulation,anti-tumor and anti-fertility.TWHF have been used for the therapy of inflammation and autoimmune diseases including rheumatoid arthritis,immune complex nephritis and systemic lupus erythematosus clinically.However,it is well known that TWHF has small margin between the therapeutic and toxic doses and could cause serious injury on digestive,reproductive and urogenital systems.Among all the organs,liver is one of the most remarkable targets of TWHF-induced toxicities,and the damage is more serious than others.It is generally accepted that TWHF-induced liver injury is a result of the combined effects of toxic elements of TWHF.It is reported in several studies that the mechanism of TWHF-induced liver injury may be related to lipid peroxidation,cell apoptosis and so on.Licorice is one of the most commonly used Chinese herbal medicine,with effects of heat-clearing and detoxicating,anti-inflammatory and hepatoprotective,reconciling various drugs,and so on.Licorice often accompany TWHF in clinical application which can significantly reduce the liver injury induced by TWHF.The attenuated effect is exact,but the mechanism is still a lack of in-depth study.This paper reviews the studies on TWHF-induced liver injury and the related mechanism as well as licorice and other traditional Chinese medicine accompany TWHF to reduce the injury in recent years,so as to provide reference for related research in the future.更多还原