妊娠相关蛋白A(PAPP-A)对妊娠期高血压疾病孕妇胎盘病理改变的影响

【作者】 李召梅； 袁秀红；

【机构】 陕西省延安富县县医院； 延安大学附属医院；

【摘要】 目的:探讨PAPP-A对妊娠期高血压疾病孕妇胎盘病理改变的影响。方法:筛选于我院进行产前检查的单胎孕妇236例作为研究对象。根据连续血压监测诊断结果分为妊娠期高血压疾病组与对照组,采集清晨空腹静脉血应用ELISA法检测PAPP-A指标,并收集产后胎盘组织进行HE染色观察。结果:妊娠高血压疾病组PAPP-A明显低于对照组孕妇(P<0.05);病理染色结果显示妊娠高血压疾病组胎盘病理改变率明显高于对照组孕妇,且病理变化类型存在差异性(P<0.05)。结论:妊娠期高血压疾病孕妇其胎盘组织可发生不同程度、不同类型的病理改变,并且妊娠期高血压疾病及胎盘病理改变与孕妇的血清PAPP-A指标具有密切关系。更多还原

【Abstract】 Objective:To explore pathological changes placenta hypertension of pregnancy pregnant women PAPP- A.Methods:the screening of prenatal care in our hospital 236 cases of singleton pregnant women as a research object.Based on continuous blood pressure monitor and diagnosis results into hypertension group and control group,detecting PAPP- A index using ELISA method and HE stain of placenta.Results:the PAPP- A pregnancy hypertension significantly lower than the control group(P < 0.05) pregnant women;staining results show hypertension pregnancy placenta pathological change rate is obviously higher than the control group of women,and the pathologic changes the type differences(P < 0.05).Conclusion:there is variation placenta pregnant women with HDCP,serum PAPP- A and pathological changes in pregnant women and relationship between index.更多还原