【作者】 赵善瑶； 刘敏； 罗文娟； 吴瑗； 刘桂波；

【机构】 青岛大学附属医院；

【摘要】 目的:观察玻璃体腔注射雷珠单抗治疗高血压视网膜中央静脉阻塞继发黄斑水肿的可行性及有效性。方法:收集于2013年2月到2014年9月前来我院就诊的高血压视网膜中央静脉阻塞继发黄斑水肿患者共30例,对所有30例患者实施玻璃体内注射雷珠单抗(ranibizumab)0.05ml(0.5mg),观察所有患者在手术前及手术后一周以及术后一个月的最佳矫正视力(best corrected visual acuity,BCVA),使用光学相关断层扫描(OCT)检查黄斑区中心凹厚度(central macular thickness,CMT),同时监测是否有术后不良反应发生。结果:经过对患者进行玻璃体内注射雷珠单抗,术后患者最佳矫正视力(BCVA)得到明显提升,其差异具有统计学意义(P<0.05)。经过对患者进行玻璃体内注射雷珠单抗术后患者黄斑区水肿明显改善,其差异具有统计学意义(P<0.05)。术后未见与药物和手术有关的不良反应发生,手术具有安全可行性。结论:玻璃体内注射雷珠单抗治疗高血压视网膜中央静脉阻塞继发黄斑水肿,能够明显改善患者视力,有效解除黄斑水肿的问题,并且手术操作简便,安全性高,术后能得到满意的效果,值得在临床上进行推广应用。更多还原

【Abstract】 Objective:To observe the feasibility and efficacy of intravitreal injection of ranibizumab treatment of macular edema secondary to hypertension central retinal vein occlusion.Methods:30 cases of macular edema secondary to hypertension central retinal vein occlusion were treated from February 2013 to September 2014.They were given Intravitreal injection with ranibizumab 0.05 ml.Then,observing the BCVA and CMT of the patients one week and one month after the operation.Results:The BCVA and CMT was better than that before the operation,the differences had statistical significance(P <0.05).Conclusion:Intravitreal injection of ranibizumab treatment of macular edema secondary to hypertension central retinal vein occlusion can improve visual acuity significantly,relieve macular edema effectively,and it is easy to operate with high safety.It also can get satisfactory effect after operation.So it is worth to applicated in clinical.更多还原