【作者】 张丹； 邱飞； 王立强； 刁勇；

【Author】 Dan Zhang;Fei Qiu;Liqiang Wang;Yong Diao;Institute of Molecular Medicine,Huaqiao University;School of Biomedical Science,Huaqiao University;Engineering Research Center of Molecular Medicine,Ministry of Education;

【机构】 华侨大学生物医学学院； 华侨大学分子药物研究院； 分子药物教育部工程研究中心；

【摘要】 以壳聚糖和甲基丙烯酰-聚乙二醇-丁二酸酯为原料,通过模板聚合法在水溶液中制备得到壳聚糖-聚(甲基丙烯酰-聚乙二醇-丁二酸酯)纳米载体。以5-氟尿嘧啶为模型药物,考察了壳聚糖-聚(甲基丙烯酰-聚乙二醇-丁二酸酯)纳米载体在体外不同pH值的缓冲液中的释放情况,采用DDSolver软件对其药物释放模型进行了拟合,根据相关系数r和AIC信息准则对各种拟合模型进行综合分析和评价。结果显示,该载体释药具有pH依赖性:在pH=7.4时释放速率最慢,累积释放量最小,在pH=5.5时释放速率最快,累积释放量最大;在不同pH值下拟合得到的药物释放均以Gompertz一级模型更具拟合优势,更能反映出该类纳米载体的药物释放规律。更多还原

【Abstract】 A kind of PEG modified nanoparticles, Chitosan-poly(methacryloyl polyethylene glycol succinic acid) nanoparticles(CSPEGNPs), was successfully prepared based on chitosan and bifunctional PEG(methacryloyl polyethylene glycol succinic acid)(MA-PEG-SA) in aqueous solution by template polymerization. Using 5-fluorouracil(5-FU) as a model drug, drug release behaviors of CSPEGNPs and release model were investigated in vitro. 5-FU-CSPEGNPs displayed certain pH sensitivity release behaviors in vitro and Gompertz first-order kinetic model could fit the release of 5-FU-CSPEGNPs better.更多还原