【作者】 李明霖； 祁潇涵； 邝允； 罗亮； 孙晓明；

【Author】 Minglin Li;Xiaohan Qi;Yun Kuang;Liang Luo;Xiaoming Sun;State Key Laboratory of Chemical Resource Engineering,Beijing University of Chemical Technology;

【机构】 化工资源有效利用国家重点实验室,北京化工大学；

【摘要】 金纳米组装体由于其稳定性、生物相容性和优异的光学性能,被广泛应用于生物成像、药物传输、生物检测等医学领域。传统的组装方法合成的金纳米链容易造成团聚,组装体尺寸大,不利于应用于生物体系,密度梯度离心可以精确控制反应时间,迅速改变化学环境[1]。本课题通过密度梯度离心的方法,在离心管中实现金纳米颗粒的组装[2]、包覆和分离等一体化的过程,并且通过改变各梯度层长度,离心转速以及溶液浓度对组装过程实现了准确控制,最终合成并分离得到了不同组装状态下的金纳米组装体。更多还原

【Abstract】 Au nanoparticles are widely used in biological imaging,drug delivery,biological detection and other medical fields due to its stability,biocompatibility and excellent optical property.Traditional assembly methods of Au nanoparticles cause reunion.The oversized assembly is not conducive to applied in biological systems.Density Gradient Separation has been employed as a process-analysis microsystem,intermediates formed within several minites were captured.The assembly,coating and separation of Au nanoparticles were happened in one tube through density gradient centrifugation.By changing the length of the gradient layer,centrifugal rotational speed and solution concentration,different assemblies of Au nanoparticles were achieved.更多还原