【作者】 游书力；

【Author】 Shu-Li You;State Key Laboratory of Organometallic Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences;

【机构】 中国科学院上海有机化学研究所金属有机国家重点实验室；

【摘要】 本次报告将重点汇报一下本小组在金属铱催化不对称烯丙基去芳构化反应领域的进展。更多还原

【Abstract】 In this talk, we present our results toward the development of Ir-catalyzed asymmetric allylic dearomatization reactions. By utilizing Ir-catalyzed asymmetric allylic substitution reaction, we have achieved the dearomatization reaction of indoles, pyrroles, phenols, and pyridines, affording various highly functionalized heterocycles bearing all-carbon quaternary chiral centers in most of the cases. In addition, the stereospecific migration of the dearomatized spiroindolenines has also been realized. The mechanistic investigation and computational study have been carried out to reveal the migration phenomenon. All these results provide not only the efficient synthesis of highly enantioenriched spiro- or polycycles, but also a novel concept in the field of asymmetric catalysis.更多还原