【作者】 李文迪； 姚宏伟； 徐智； 石雪迎； 张元福； 徐怡庄；

【Author】 LI Wen-di;YAO Hong-wei;XU Zhi;SHI Xue-ying;ZHANG Yuan-fu;XU Yi-zhuang;Department of General Surgery,Peking University Third Hospital;Department of Pathology,Peking University Health Science Center;College of Chemistry and Molecular Engineering,Peking University;

【机构】 北京大学第三医院普通外科； 北京大学医学部病理学系； 北京大学化学与分子工程学院；

【摘要】 探索红外光谱用于判断结直肠癌手术切缘的可能性。运用博里叶变换红外光谱仪联合中红外光纤及ATR探头检测手术切除的新鲜结直肠癌标本(17例),分别测定肿瘤中心和距肿瘤边界2cm的对应肠浆膜面的反射红外光谱。将光谱特征进行统计分析发现,对于TMN肿瘤分期T≤2(即肿瘤未侵及浆膜层)的结直肠癌,肿瘤中心和距肿瘤边界2 cm对应的肠浆膜的光谱特征之间无统计学差异;而对于TNM分期T≥3(即肿瘤侵及浆膜层)的结直肠癌,两者之间的光谱特征有明显差异。结果表明,博里叶变换红外光谱分析可以应用于肿瘤侵犯浆膜层(T≥3)的结直肠癌术中手术切缘的判断。更多还原

【Abstract】 To explore the feasibility of Fourier transform infrared spectroscopic method(FTIR) for judging resection margin of colorectal cancer,seventeen fresh colorectal cancer samples were collected during surgery and were measured by FTIR via of attenuated total reflection probe(ATR).FTIR spectra of the serosal surface of the centre of tumors and that of the site 2 cm away from the tumors’ boundary were measured.Statistical analysis indicate that the FTIR spectra of colorectal cancer’s serosal surface was almost the same as that of the normal serosa in T≤2 for TNM staging tumors,which means cancer has not affected serosa.While,difference were found in T≥3 for TNM staging tumors,which means the serosa with tumor invasion.It is concluded that the FTIR maybe used to judge resection margin of colorectal cancer when the tumor has affected its serosa(T≥3).更多还原