【作者】 赵颀涵； 罗琼； 向春燕； 李菁菁； 耿天琪； 阎俊；

【Author】 Zhao Qi-han Luo Qiong Xiang Chunyan Li Jingjing Geng Tianqi Yan Jun (School of Public Health,WuhanUniversity,Wuhan,430071,China)

【机构】 武汉大学公共卫生学院营养与食品卫生学系；

【摘要】 目的:研究LBP对糖尿病所导致的勃起功能障碍的影响,为构杞多糖预防DIED提供理论依据。方法:四氧嘧啶造模,测阴茎组织的ICP,用试剂盒测海绵体SOD、GSH-PX、NOS的活力和MDA、GSH、NO的含量。结果:LBP能显著提高糖尿病兔阴茎的△ICP值,提高SOD、GSH-PX的活力,降低MDA含量,增加GSH的含量,提高机体的抗氧化能力,同时提高NOS的活性、N0的含量。以上各指标,预防组效果明显好于治疗组。结论:LBP能明显改善糖尿病导致的阴茎勃起功能障碍。可能的机制是LBP改善兔阴茎组织氧化防御系统,上调阴茎组织中NO的含量以及NOS的活性。更多还原

【Abstract】 Objective:To investigate the influence of Lycium barbarum polysaccharides(LBP) on erectile dysfunction induced by diabetic,provide the theory basis for the LBP prevention DIED.Method;make model by alloxan, test ICP,test the vitality of SOD,GSH-PX and NOS and the content of MDA,GSH,NO of penile tissue.Result: LBP can significantly improve AICP value,enhance the vitality of SOD,GSH-PX,reduce the content of MDA and increase GSH,enhance the antioxidant capacity of penis of diabetic rabbit.LBP can increase the activity of NOS and the content of NO at the same time.Above all indexs,the effect of prevention group is more better than treatment group.Conclusion;LBP can obviously improve erectile dysfunction.The mechanism may be related to LBP improve oxidative defense system of rabbit penile tissue,increase the content of NO and the activity of NOS in penis.更多还原