Highly Enantioselective Pictet-Spengler Reaction Catalyzed by SPINOL-Phosphoric Acids

【作者】 黄丹； 林旭峰； 王彦广；

【Author】 Dan Huang,Xufeng Lin,Yangguang Wang Department of Chemistry,Zhejiang University,Hangzhou 310027,P.R.China

【机构】 Department of Chemistry,Zhejiang University；

【摘要】 <正>Chiral tetrahydro-β-carbolines represent an important class of heterocycles in organic chemistry.They are structural units in a variety of natural products,and important pharmaceuticals and useful intermediates for constructing several drugs.Consequently,efficient methods for the preparation of optically pure tetrahydro-β-carbolines are in great demand.Recently,we designed and synthesized a novel class of chiral SPINOL-phosphoric acids as Brφnsted acids,which possess geometrically different and more rigid chiral parameters compared with the classic BINOL-phosphoric acids.l Herein,we describe the first更多还原