High-Throughput Next-Generation Sequencing-Based Solutions to Cardiovascular Disease

【作者】 胡敏珊； 方定志；

【机构】 四川大学华西基础医学与法医学院生物化学与分子生物学教研室；

【摘要】 <正>Cardiovascular Disease(CVD) has been shown to be highly heritable,with heritability as high as 60%.However,despite the rapid identification of novel targets for CVD and its risk factors,few have been translated into clinical practice. Whereas Genome-wide association studies(GWASs) have had great success in identify-ing genetic loci associated with CVD,many challenges exist.First,these studies typically use only single-nucleotide polymorphisms(SNPs) that occur at a frequency of 1%.Thus,更多还原