【作者】 王顺； 王永涛； 贾征夫；

【机构】 武汉市第一医院检验科；

【摘要】 目的了解我院慢性阻塞性肺疾病(COPD)患者肺部感染铜绿假单胞菌(PAE)的耐药性,为临床医师正确诊断疾病与合理用药提供实验依据。方法铜绿假单胞菌培养鉴定严格按照《全国临床检验操作规程》进行;药物敏感试验采用KB法,结果判断按照CLSI折点评价:采用WHONET 5.4版本统计分析实验数据。结果 133株铜绿假单胞菌对亚胺培南和美罗培南耐药率分别为29.3%(39/133)、31.6%(42/133),对其他常用抗菌药物也产生了不同程度的耐药性。PAE泛耐药株检出率为12.0%(16/133)。结论 COPD患者肺部感染铜绿假单胞菌的耐药性已十分严重,临床医护人员应加强监测与控制力度。更多还原

【Abstract】 OBJECTIVE To understand the antibiotical resistance of Pseudomonas aeruginosa (PAE) causing pneumonia from patients with chronic obstructive pulmonary diseases(COPD) and provide the experimental evidence for clinically correct diagnosis of diseases and reasonable use of antibiotics.METHODS Referring to National guide to clinical laboratory procedures,PAE were cultured and identified.The antibiotical susceptibility testings were performed by K-B methods.The susceptibility testings results were assessed according to CLSI breakpoints and analyzed statistically by WHONET 5.4 software.RESULTS The resistance rates of imipenem and meropenem were 29.3%(39/133) and 31.6%(42/133),respectively. The varying antibiotical resistance existed in the other commonly used antibiotics.The detection rate of pan-resistant strains was 12.0%(16/133).CONCLUSIONS The antibiotical resistance of PAE causing pneumonia from patients with COPD was increasing serious.We should strengthen monitoring and controlling of it.更多还原