【作者】 杨季冬； 李勤；

【Author】 YANG Ji-dong~(1,2),LI Qin~1 1.School of Chemistry and Chemical Engineering,Southwest University,Chongqing 400715,China 2.School of Chemistry and Chemical Engineering,Yangtze Normal University,Chongqing 408100,China

【机构】 西南大学化学化工学院； 长江师范学院化学化工学院；

【摘要】 在pH 4.2～4.8的BR缓冲介质中,氟喹诺酮类抗生素（FLQs）能与铜（Ⅱ）形成螯合阳离子,又与虎红（Tf）阴离子通过静电引力和疏水作用形成FLQs:Cu（Ⅱ）:Tf为1:1:1的离子缔合物,体系反应导致共振瑞利散射（RRS）显著增强并出现新的RRS光谱。两种药物的反应产物具有相似的光谱特征,最大RRS峰位于373 nm处。两种氟喹诺酮类药物的线性范围分别是.031～7.8μg·mL^-1（MXFX）和0.029～9.0μg·mL^-1（GTF）。据此可建立用于测定氟喹诺酮类药物的新方法,方法用于胶囊和人尿液中的FLQs测定并取得满意结果。文中还对反应机理和RRS增强的原因作了讨论。更多还原

【Abstract】 In pH 4.2-4.8 Britton-Robinson（B-R） buffer solution,Moxifloxacin（MXFX） and Gatifloxacin（GTF） of fluoroquinolone antibiotics（FLQs） could react with Cu（Ⅱ） to form chelate cations,which further binded with tetrachlorotetraiodo-fluoresceindisodium salt（Tf） to form FLQs:Cu（Ⅱ）:Tf 1:1:1 ion association complexes.The system reactions resulted in the great enhancement of resonance Rayleigh scattering（RRS） and new RRS spectra appear.Their reaction products of the two drugs had similar spectral characteristics,the maximum RRS wavelengths were situated at 373 nm,the intensities of RRS were proportional to the concentration of antibiotics drugs,the linear range of two drugs were 0.030 9-7.8μg ? mL^-1（MXFX） and 0.029 1-9.0μg ? mL^-1（GTF） espectively.So a new method for determination of the drugs could be developed and succeed to applied to determine content of the FLQs in Capsule and human urine sample.The reaction mechanism and the reasons for RRS enhancement of the system were investigated in the paper.更多还原