【作者】 任毅； 陈可冀； 张敏州； 尤士杰； 郭力恒； 张健； 吕渭辉；

【Author】 REN Yi 1,CHEN Ke-ji 2,ZHANG Min-zhou 1,YOU Shi-jie 3,GUO Li-heng 1,ZHANG Jian 3,LV Wei-hui 1(1 Guangdong Provincial Hospital of TCM,Guangzhou 510120;2 Xiyuan Hospita1,China Academy of Chinese Medical Science,Beijing 100091;3 Fuwai Cardiovascular Disease Hospita1,Chinese Academy of Medical Science,Beijing 100037)

【机构】 广东省中医院； 中国中医科学院西苑医院； 中国医学科学院阜外心血管病医院；

【摘要】 目的:探讨冠心病中医证型与大内皮素、N末端脑钠肽之间的相关性。方法:将405例冠心病患者按中医辨证为气虚、阴虚、阳虚、气滞、血瘀、寒凝、痰浊七个证型,检测其血浆BigET-1和NT-proBNP水平,并进行比较。结果:血瘀及兼证、非血瘀证两组比较,Big-ET1差异有统计学意义(P<0.05);阳虚及兼证、非阳虚证两组比较,寒凝及兼证、非寒凝证两组比较,NT-proBNP差异有统计学意义(P<0.05);冠心病不同西医分型比较,NT-proBNP差异有统计学意义(P<0.05)。结论:血瘀证可能和BigET-1相关,阳虚证、寒凝证可能和NT-proBNP相关,BigET-1、NT-proBNP可能作为冠心病辨证分型的客观指标。更多还原

【Abstract】 Objective:To explore the relativity between TCM syndromes of coronary heart disease(CHD) and the plasma concentration of Big endothelin-1(Big ET-1)、 N—terminal probrain natriuretic peptide(NT-proBNP).Method:405 CHD patients were divided into 7 TCM syndromes,Qi deficiency syndrome(QDS),Yang asthenia syndrome(YAS),Yin deficiency syndrome(YDS),Qi stagnation syndrome(QSS),cold coagulation syndrome(CCS),blood stasis syndrome(BSS) and phlegm-turbid syndrome(PTS),and the plasma concentrations of Big ET-1 and NT-proBNP were measured and compared.Result:Differences of NT-proBNP have statistics significance in comparison between BSS and accompanied syndromes and non-BSS(P<0.05);Differences of Big-ET1 had statistics significance in comparison between YAS and accompanied syndromes and non-YAS(P<0.05),and between CCS and accompanied syndromes and non-CCS(P<0.05).Conclusion:BSS possibly had a relationship with Big ET-1,YAS and CCS were possibly correlation with NT-proBNP,Big ET-1 and NT-proBNP possibly were biochemistry material base of different TCM syndromes of CHD.更多还原