【作者】 任周新； 许前磊； 李青雅； 左刚；

【Author】 Ren Zhou-xin~(1,2),Xu Qian-lei~1,Li Qing-ya~1,Zuo Gang~1. (1.AIDS Institute of Henan University of TCM;Zhengzhou 450008;China;2.Henan Key Laboratory of Viral Diseases Control with TCM,Zhengzhou 450008,China)

【机构】 河南中医学院艾滋病研究所； 河南省病毒性疾病中医药防治重点实验室；

【摘要】 目的 :探讨薯蓣丸对Friend病毒模型小鼠免疫功能的影响。方法 :Friend病毒攻击小鼠,同时施用不同剂量的薯蓣丸进行干预,连续用药3周。取血,处死动物,称取脾脏,ELISA法检测血浆中IL-2、IFN-?及IL-6含量;流式细胞术检测CD4+T、CD8+T细胞百分率。结果 :与模型组比较,给药后动物的体重、脾脏重量、脾指数及IL-2、IFN-?及IL-6含量和CD4+T、CD8+T细胞百分率均没有显著性差异(p>0.05)。结论 :薯蓣丸对Friend病毒感染小鼠的免疫功能没有明显的影响。更多还原

【Abstract】 Objective:To observe the effect of ShuYuWan on the immunity of murine AIDS (MAIDS) caused by the Friend murine leukemia virus(FLV).Methods:Experimental model was estabhshed by inoculated intraperitoneally(ip) with FLV in mice,and treated with drugs every day for 21 days.21 days after infection,blood was taken to assay IL-2,IFN-? and IL-6 in plasma and the percentage of CD4+T lymphocyte/total lymphocyte and CD8+T lymphocyte/total lymphocyte in peripheral blood.Results:Compared with the model group,all indexes were not markedly different in the three ShuYuWan groups(P>0.05).Conclusion:ShuYuWan could not ameliorate immunity of f murine AIDS(MAIDS) caused by the Friend murine leukemia virus.更多还原