【作者】 刘世利； 王红艳； 贾继辉；

【Author】 Liu Shili,Wang Hongyan,Jia Jihui Institute of Pathogen Biology,Me dical College,Shangdong Medical University

【机构】 山东大学医学院病原生物学研究所；

【摘要】 <正>生长因子Progranulin(PGRN)是一种分泌型糖蛋白,在细胞转化、生长和转移中发挥重要的调节功能。本文研究发现幽门螺杆菌感染情况下胃部上皮细胞中的PGRN表达上调,因而围绕PGRN的功能与幽门螺旋杆菌感染之间的关系展开研究,发现PGRN与胃上皮细胞的增殖和转移有相关性。首先检测了胃炎和胃癌患者胃部组织和胃上皮细胞系中PGRN的表达,同时测定了细胞的增殖和转移能力。结果发现,在胃炎和胃癌患者组织中PGRN蛋白表达量明显升高,体外实验表明在PGRN胃上皮细胞系中表达也显著增加,并呈更多还原

【Abstract】 Progranulin(PGRN) functions as an important regulator of cell growth,migration,and transformation. We determine the molecular mechanisms by which H.pylori upregulates PGRN and its function in controlling cell proliferation and migration.The results demonstrated that PGRN protein levels were increased in patients. The activation of p38 and MEK1/2 pathway by H.pylori mediated PGRN upregulation,suggesting that the upregulation of PGRN in H.pylori-infected gastric epithelial cells may contribute to the carcinogenic process.更多还原