【作者】 陈瑞清； 俞道进； 陈锋； 黄一帆；

【Author】 CHEN Rui-qing~(1,2),YU Dao-jin~1,CHEN Feng~2,HUANG Yi-fan~(1*) (1.College of Animal Science,Fujian Agriculture and Forestry University,Fuzhou 350002; 2.Fujian Inspection and Testing Centre for Agricultural Product Quality and Safety,Fuzhou 350003)

【机构】 福建农林大学动物科学学院； 福建省农产品质量安全检验检测中心；

【摘要】 建立了鸡血浆中癸氧喹酯残留量的高效液相色谱-串联质谱测定方法。选用10只健康青脚麻鸡,按10mg/kg b.w.的剂量进行单次灌服癸氧喹酯在肉鸡体内的药物动力学研究。肉鸡口服给药癸氧喹酯的血浆药时数据符合一级吸收二室开放模型,主要药动学参数:吸收半衰期为2.614h,分布半衰期为3.944h,消除半衰期为19.334h,达峰时间长达15h,达峰浓度较低,为43.048ng/mL,药物在血浆中的平均滞留时间为47.065h。结果表明内鸡口服癸氧喹酯后吸收慢且不完全,但吸收进入血浆中的癸氧喹酯消除缓慢。更多还原

【Abstract】 A high performance liquid chromatography-tandem mass spectrometry（LC-MS/MS） method was developed for the determination of decoquinate residue in chicken blood.After being orally administrated decoquinate with a single dose of 10 mg/kg b.w.,the study on pharmacokinetics of decoquinate in chicken plasma was conducted.The concentration-time data was fit to the two-compartment open model with the first order absorption.The t_1/2ka,t_1/2α t_1/2β and MRT_0-∞ Were 2.614h,3.944h,19.334h and 47.065h respectively,and the T_max and C_max were 15h and 43.048 ng/mL respectively,which indicated that the absorption of decoquinate was slow and incomplete,and the elimination of decoquinate in plasma was also slow.更多还原