【作者】 秦艳芳； 王广泉； 张慧敏； 武文英； 吴昊； 杜黎明；

【Author】 Yan-fang Qin,Guang-quan Wang,Hui-min Zhang,Wen-ying Wu,Hao Wu,Li-ming Du Analytical and Testing Center,Shanxi Normal University,Shanxi Linfen 041004

【机构】 山西师范大学分析测试中心；

【摘要】 <正>褪黑素(MLT)是松果体内分泌的一种吲哚类激素,具有广泛的生理活性,能促进T、B淋巴细胞的增殖抑制肿瘤的生长。葫芦[5]脲(CB[5])是由6个苷脲单元和12个亚甲基更多还原

【Abstract】 Cucurbit[5]uril is a new generation of supramolecular host with good rigidity hydrophobic cavity that can accommodate a variety of guest molecules selectively.To date,no studies have been reported on the interaction of CB[5] with Melatonin(MLT).It is found that the fluorescence intensity of the MLT complex decreased gradually with the increasing concentration of CB[5].At the same time,the hypochromicity of the absorption spectra of MLT was observed.This modification of the spectra was considered to be a result of inclusion complex formation between the MLT and CB[5].Association constant and the stoichiometry of the inclusion complex have been studied according to the Stern-Volmer equation.The data indicated a 1:1 inclusion complex forms between CB[5] and MLT.These studies provide a theoretical guide for the expansion of cucurbituril in the field of drug analysis applications.更多还原