【作者】 王丹； 曲凤玉；

【Author】 wangdan, qufengyu * 1 Department of Chemistry, Harbin Normal University,Harbin , 150025

【机构】 哈尔滨师范大学化学化工学院；

【摘要】 本文成功的采用一步法合成磁性大孔/介孔复合孔生物活性玻璃(MMBG),主要采用廉价的盐刻蚀技术作为大孔模板,于此同时非离子型三嵌段共聚物P123不仅作为介孔模板剂,而且作为还原剂,在P123高温分解过程中铁源被还原成磁流体。合成(MMBG)的方法简单,易操作。加之,制备的复合孔生物活性玻璃具有连通的大孔(200-300μm)结构和介孔(2-10nm)结构。进一步研究表明(MMBG)对药物具有良好的组装/缓释性质,在浸泡在模拟人体液(SBF)中12小时后可诱导羟基磷灰石(HAP)的快速生成,这种新型的材料(MMBG)可作为磁热疗试剂,从而提高药效并在骨癌和骨肿瘤的治疗方面具有潜在的应用。更多还原

【Abstract】 the magnetic and macro/mesoporous bioactive glass (MMBG) has been synthesized on one-step. The low-priced salt leaching processing technique was used to make macroporous structure. P123 was not only used as the mesopoeous template, but also the reductant. The iron source can be reduced to magnetic fluid by the thermal decomposition product of P123. It is a simple method to obtain the magnetic macro/mesoporous bioactive glass materials. Simultaneously, the as-prepared materials have interconnected macroporous (200-300 μm) and mesoporous (3.4 nm). The as-prepared MMBG showed the well drug storage/release properties and fast formation of hydroxyapatite (HAP) after immersed 12h in Simulated Body Fluid(SBF) The new materials can be used as the magnetic fluid hyperthermia regent to improve the effect of drug, that makes them have the well potential application on the therapy of osteocarcinoma and bone neoplasms.更多还原