【作者】 郭伟； 曲凤玉；

【Author】 Wei Guo,Fengyu Qu * Inorganic chemistry,University of Harbin Normal University,Harbin Normal University,Harbin,150025

【机构】 哈尔滨师范大学；

【摘要】 通常,介孔硅材料的表面修饰上一层包裹剂可以使其具有较好的药物释放动力学特性,如:PLGA、PHBV,一些DNA,一些蛋白质等。在这篇文章中,我们使用生物活性玻璃进行表面的矿化,实现一步载药和矿化的过程。由于羟基磷灰石的降解,这个系统显示出较好的PH响应呐能力。然而,据我们所知,现在很少有人使用无机层来控制药物的释放。我们在体外研究了在不同的PH值和载药时间下,药物的释放能力。最后我们得到了一种简单,新颖的纳米载药体系。更多还原

【Abstract】 Generally,the use of organic materials to modify the mesoporous silica materials make the well drug release kinetics,Such as,poly(lactide-co-glycolide)(PLGA),Poly(hydroxybutyrate-polyhydroxyvalerate)(PHBV),DNA,and proteins.In this paper,we use the mineralization of hydroxyapatite of bioactive glass mesoporous materials in SBF to realize the drug loading and inorganic shell mineralization at one step.Because of the hydroxyapatite degradation,the system shows the well PH-sensing drug delivery ability.However,to the best of our knowledge,there are few reports using an inorganic layer to control the release of the drug.We studied the drug release properties in vitro under different PH and loading time.Finally,we get a simple and novel nano-carrier system.更多还原