【作者】 肖绚； 胡瑄； 邵世煌；

【Author】 Xiao Xuan 1,Hu Xuan 1,Shao Shihuang 2 1.Computer Department,Jing-De-Zhen Ceramic Institute,Jing-De-Zhen 33300,P.R.China 2.Institute of Information,Donghua University,Shanghai 200051,P.R.China

【机构】 景德镇陶瓷学院机电学院； 东华大学信息学院；

【摘要】 现有的乙肝病毒感染细胞动力学模型,都是基于病毒和肝细胞在肝组织中均匀分布的假设之上的。研究表明时空特性在乙肝病毒感染的发展和爆发中潜在地起着重要作用,如被免疫系统所清除的感染肝细胞(也就是死亡肝细胞)可能影响病毒的感染速度等。本文基于二维概率粗粒化元胞自动机对乙肝病毒动力学进行了建模,分析了模型参数对动力学性质的影响。仿真结果表明模型能很好地模拟乙肝病毒感染细胞过程,并能模拟不同药物作用下的治疗效果。更多还原

【Abstract】 The basic model of hepatitis B virus(HBV) infection dynamics,are based on the assumption of well-mixed virus and cell populations.But spatial characteristics potentially play a nontrivial role in the development and outcome of a HBV infection,such as localized populations of dead cells might adversely affect the spread of infection.Here,we use a 2-D coarse-grained cellular automata model to study the evolution of HBV infection.We also consider the effects of the model’s parameters on the dynamics of the infection.The simulation results show that the model is powerful in simulating the process of HBV infection cell,and can be used to simulate the curative effects of different medication.更多还原