急性胰腺炎患者的血浆DD变化及意义

【作者】 付璐； 李琳； 张艳芬； 李洁； 张云平；

【机构】 哈尔滨医科大学附属第一医院检验科；

【摘要】 通过对急性胰腺炎患者体内中等长度DD片段的检测,进一步证实AP患者止凝血系统的变化及意义。选择94例急性胰腺炎患者(其中MAP42例、SAP52例),健康对照组50例。收集血常规,凝血指标(PT),活化的部分凝血活酶时间(APTT),纤维蛋白原(FIB)及D-二聚体(D-dimmer),生化指标(肝、肾功能、血糖、血钙),血气分析,血、尿淀粉酶,腹部B超以及腹部CT检查等情况,计算出入院24h内的APACHEⅡ评分。组间比较采用t检验,两因数之间的相关性用直线相关分析。最终得出结论:1.SAP患者中凝血、纤溶系统被激活,2.APACHEⅡ评分较为繁琐而且耗时较长,而中等片段的DD指标可以更好地反映病情以及未来的预后。3.关注急性胰腺炎患者止凝血系统的变化,有助于了解AP患者微循环障碍情况,为临床纠正凝血功能紊乱,改善预后提供依据,以提高AP治愈率。更多还原

【Abstract】 Based on the detection of medium length DD fragment of the patients with acute pancreatitis in vivo,we want to confirmed with changes and significance of coagulation system in AP patients.We choose 94 cases of patients with acute pancreatitis(MAP 42,SAP 52),and Healthy control group of 50 cases;and collected blood routine,PT,APTT,FIB and D- dimer,biochemical (liver,renal function,blood glucose,serum calcium ),blood gas analysis, blood,urine amylase,abdominal B ultrasound and abdominal CT examination etc., computing hospital within 24 h of APACHEⅡscore.Comparisons between groups were tested by T-test,two factor correlations between linear correlation analysis.Final conclusion:1.in SAP patients,coagulation and fibrinolytic system is activated;2.the score of APACHEⅡis more complex and time consuming,and secondary fragments of the DD index can better reflect the illness and the prognosis for future;3.Paying attention to the coagulation system changes of acute pancreatitis patients,will contribute to the understanding of AP microcirculation in patients with clinical situation,for the correction of coagulation disorders,improve prognosis and improve the cure rate of AP.更多还原