【作者】 戴秋萍； 厉曙光； 余金明； 陈芳； 张敬； 张志强；

【Author】 Dai Qiuping,Li Shuguang,Yu Jinming,Chen Fang,et al. Department of Preventive Medicine,College of Basic Medical,Tongji University,Shanghai 200070,China

【机构】 同济大学基础医学院；

【摘要】 为了解核酸对人体抗氧化作用的影响,对某核酸胶囊进行了动物和人体实验研究。采用老龄大鼠抗氧化试验:取老龄雌性SD大鼠32只,分低、中、高剂量组和老龄对照组,每组8只。剂量组饮用核酸胶囊配制成的饮水,对照组则饮用普通水,连续饮用50d。第51天测血清丙二醛(MDA)含量、超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GSH-Px)活性;人体试食试验:选取50～65岁居民120人,试食组和对照组各60人。受试者每天服用6粒胶囊。试食组服用核酸胶囊,对照组服用除核酸外其余成分均相同的胶囊,为期两个月。于第61天,测血清MDA、SOD和GSH-Px。结果显示,老龄大鼠抗氧化试验显示各剂量组大鼠血清MDA含量均明显低于对照组(P<0.01),低、中剂量组血清SOD活力明显高于对照组(P<0.01,P<0.05),各剂量组大鼠血清GSH-Px活力均明显高于对照组(P<0.01);人体试食试验显示试食组血清SOD活力高于对照组(P<0.05),而血清MDA、GSH-Px与对照组比较无显著性差异(P>0.05),试食组的食欲、精神、气力三项主观指标比对照组的有明显改善(P<0.05)。提示核酸胶囊对老龄大鼠有明显抗氧化作用;而单独的核酸可以提高人体SOD活性,并对人体食欲、精神和气力有促进作用。更多还原

【Abstract】 To study the antr oxidation function of nucleic acids both in animal experiment and in human.(1) Antioxidation test in aged rats:Using 32 aged female SD rats,divided into 3 dose groups and 1 control group.Each group had 8 rats.Mixing deferent doses nucleic acid capsule with drinking water and fad doses groups for 50 days.The control group was given only drinking water.On 51st day,measuring the serum malondialdehyde(MDA),superoxide dismutase(SOD) and glutathione peroxidase(GSH-Px).(2) Eating observation test in aged people:Choosing 120 volunteers aged 50 65 who came from some community in Shanghai,divided into eating observation group and control group.Each group had 60 people.Each people ate 6 capsules per day for 60 days.The control group used same capsule except nucleic acids.On 61 st day,measuring the serum MDA,SOD and GSH-Px.Results Antr oxidation test in aged rats showed that the concentrations of serum MDA in all dose groups are lower than that of the control(P < 0.01).The concentrations of serum SOD in low and middle dose groups are liigher than those of control(P< 0.01,P< 0.05).The concentrations of serum GSH-Px in all dose groups are higher than those of control(P < 0.01).Eating observation test in aged people showed that the concentration of serum SOD in eatiig observation group is higher than that of the control(P < 0.05),the concentrations of serum MDA and GSH-Px have no significant compared with the control.The appetite,vigorous and energy of eating observation group are significantly improved compared with the control(P < 0.05).Conclusion The nucleic acid capsule has antr(Kidation function in aged female SD rats.The nucleic acids alone could promote SOD and improve the appetite,vigorous and energy of human body.更多还原