【作者】 高莹； 李可基； 唐世英； 肖颖；

【Author】 Gao Ying,Li Keji,Tang Shiying,Xiao Ying Department of Nutrition and Food Hygiene,Beijing University,Beijing 100083,China

【机构】 北京大学公共卫生学院； 北京大学第三医院；

【摘要】 为建立更合理而实用的高脂血症动物模型,比较了SD大鼠、Wistar大鼠和金黄地鼠的血清和肝脏脂质对高脂饲料的反应。大鼠高脂饲料配方为1%胆固醇、10%猪油、10%蛋黄粉和79%基础饲料;金黄地鼠高脂饲料配方为0.2%胆固醇、15%猪油和85%基础饲料。结果显示,经过高脂饲料喂养5周后,SD大鼠、Wistar大鼠和金黄地鼠高脂组血清甘油三酯水平分别比对照组高194.4%、86.2%和84.3%(P<0.05),血清总胆固醇水平分别比对照组高76.8%、48.3%和134.8%(P<0.05)。提示金黄地鼠是一种良好的高胆固醇血症模型,而SD大鼠可能是一种较好的高甘油三酯血症模型。更多还原

【Abstract】 To establish a better animal model for hyperlipidemia,three animal models with SD rats,Wistar rats and golden hamsters were explored.The semi-purified diet for rats was composed of 1%cholesterol,10%lard,10%yolk powder and 79%normal diet The semi-purified diet for hamster was composed of 0.2%cholesterol,15%lard and 85% normal diet.Serum TC,TG,HDL-C,liver cholesterol and triglyceride were assayed.Serum TG of SD rat,Wistar rat and hamster was 194.4%,86 2%and 84.3%respectively higher than that of control after 5 weeks of experiment.Serum TC of the three groups was 76 8%,48.3%and 134.8%respectively higher than that of control.The results suggested that hamster might be a better animal model for hypercholesterolemia and SD rat might be tetter for hypertriglyceridemia.更多还原