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维库溴铵对兔定量药物脑电图的影响
Effects of vecuronium on quantitative pharmaco-electroencephalography in rabbits
【作者】 韩平平; 蔡慧明; 周美艳; 张明阳; 刘亚君; 郭继龙; 吴克俭; 戴体俊;
【Author】 HAN Pingping,CAI Huiming,ZHOU Meiyan,ZHANG Mingyang,LIU Yajun,GUO Jilong, WU Kejian,DAI Tijun. Xuzhou Medical College,Xuzhou 221002,China.
【机构】 徐州医学院药学院; 徐州医学院麻醉学院; 徐州医学院附属医院; 徐州医学院麻醉药理教研室;
【摘要】 目的观察维库溴铵对兔定量药物脑电图(QPEEG)的影响。方法应用QPEEG,采用功率谱分析法,分析戊巴比妥钠麻醉后的兔静脉注射维库溴铵0.3 mg·kg-1前后脑电活动的变化。结果给药前、给药后30 s、1、2、3、5、10 min各时间点比较,各脑区的各频段功率百分比均无明显改变(P>0.05);给药前后各波的振幅亦无明显改变。结论维库溴铵对兔QPEEG无明显影响。
【Abstract】 Objective The study is to investigate the effects of vecuronium on quantitative pharmaco-electroencephalography(QPEEG) in rabbits.Methods One dose of vecuronium was injected to the rabbits being anesthetized with sodium pentobarbital.The EEG samples were obtained prior to and at regular intervals following the administration of vecuronium 0.3 mg·kg-1.Using power spectral analysis to check rabbits’ EEG changes before and after the vecuronium iv injections.Results Administered before,after administration 30 s、1、2、3、5、10 min,compared at each time point,the brain power of each band was no significantly change in the percentage(P > 0.05).Amplitude of all bands,before and after vecuronium administration,was also no significantly change.Conclusions Vecuronium had no effect on rabbit QPEEG.
【Key words】 Quantitative pharmaco-electroencephalogram; Power spectral analysis; Vecuronium; Muscle relaxant;
- 【会议录名称】 第一届全国麻醉药理专业委员会第二次学术会议论文集
- 【会议名称】第一届全国麻醉药理专业委员会第二次学术会议
- 【会议时间】2011-07-15
- 【会议地点】中国河北张家口
- 【分类号】R614
- 【主办单位】中国药理学会