【作者】 庞亮亮； 孙建和；

【Author】 PANG Liang-liang SUN Jian-he (Shanghai Key Laboratory of Veterianry Biotechnology,Shanghai Jiao Tong University,Shanghai 200240,China)

【机构】 上海交通大学农业与生物学院上海市兽医生物技术重点实验室；

【摘要】 化脓性链球菌因基因变异致使毒力增强,严重威胁了人类健康。由于噬菌体与其宿主菌密切的关系,人们推测其在细菌的演化过程中发挥了重要作用。特别是上世纪80年代高致病性化脓性链球菌的再现,噬菌体可能发挥了举足轻重的作用。文中试图解释噬菌体与宿主菌的重要关系。通过对高致病性菌株M1T1的基因研究,推断出化脓性链球菌毒力演化可能的分子机制,并验证了前噬菌体在细菌毒力演化过程中的地位和作用。噬菌体在细菌毒力演化过程中扮演了一个重要角色,同时噬菌体也有可能在治疗细菌性感染中起到重要作用。更多还原

【Abstract】 Background Streptococcus pyogenes is a well-known cause of a variety of clinical infections,virulence enhanced due to genetic mutation causing a serious threat to human health.As the close relationship of phage with its host bacteria,it is speculated that the phage playing an important role in bacterial evolution.Specially,In the 80s of last century the reproduction of highly pathogenic Streptococcus pyogenes,the phage may play a pivotal role.Objective This paper describes the important relationship of phage with the host bacteria.Through the genetic research of highly toxic strain of M1T1,the molecular mechanism of Streptococcus pyogenes virulence evolution is inferred and it is verified that the position of the prophage in the bacterial virulence evolution.Conclusion Phages in bacterial virulence evolution played an important role,however it also possible play an important role in the treatment of bacterial infections.更多还原