【作者】 魏淑贞； 陈求扬； 梁庆福； 赵永； 林建； 林勇明；

【Author】 WEI Shu-zhen,CHEN Qiu-yang,LING Qing-fu,ZHAO Yong,LIN Jin,LIN Yong-ming (Fujian Center for Disease Control and Prevention,Fuzhou 3500010,China)

【机构】 福建省疾病预防控制中心；

【摘要】 目的了解初治肺结核患者不同年龄组的耐药情况,为结核病防治对策的制定提供依据。方法收集在结核病防治门诊登记的肺结核新病例的痰标本,经涂片镜检、分离培养阳性的菌株进行菌型鉴定及对一线抗结核药物(INH、RFP、SM、EMB)敏感性测定。结果 262例初治涂阳肺结核患者,总耐药率为19.85%。其中,总耐单药率为11.45%,多耐药为3.05%,耐多药率为5.34%。不同年龄组耐药率、耐多药率之间的差异无统计学意义(P>0.05)。结论初治肺结核患者单耐药和耐多药疫情较高,应加强对初治肺结核患者的治疗督导管理。建议提高对初治患者的早期发现,早期诊断,早期治疗,对于提高患者治愈率及减少耐药的发生和扩散至关重要。更多还原

【Abstract】 Objective To find out the age distribution of drug susceptibility of new cases infected pulmonary tuberculosis,aimed at providing evidence for designing the policy about TB control.Methods Sputum specimens from new cases infected pulmonary tuberculosis registered in TB dispensary were collected,through smear microscopy and culture,the culture positive strains were conducted drug susceptibility test and identification.Results The total drug resistant rate of 262 strains from new cases of pulmonary tuberculosis was 19.85%.The sing drug resistant rate was 11.45%,the resistant rate of two drugs(except of resistant to INH and RFP simultaneously) was 3.05%,the multi-drugs rate was 5.34%.The difference of drug resistant rate and MDR among age-groups was no significance(P>0.05).Conclusion Situation of drug resistance of sing drug and multi-drugs of new cases infected pulmonary tuberculosis is severe.We should lay emphasis on the supervision for treatment and management of new cases infected TB.更多还原