【作者】 车南颖； 姜世闻； 高铁杰； 李松； 张旭霞； 张慧； 张治国； 王黎霞； 李传友；

【Author】 Che Nanying~1,Jiang Shiwen~2,Gao Tiejie~3,Li Song~1,Zhang Xuxia~1,Zhang Hui~2,Zhang Zhiguo~3, Wang Lixia~2,Li Chuanyou~1 1 Beijing Tuberculosis & Thoracic cancer Research Institute,Beijing 101149 China;2 Center for Tuberculosis Control And Prevention,Chinese Center For Disease Control And Prevention, 102206 Beijing China;3 Beijing Changping Center for Tuberculosis Control and Prevention, 102200 Beijing China

【机构】 北京市结核病胸部肿瘤研究所； 中国疾病预防控制中心结核病预防控制中心； 北京市昌平区结核病防治所；

【摘要】 目的检测中国汉族人群特异TLR2基因多态性,并分析与结核病易感性之间关系。方法在小样本中测序检测TLR2基因中可能存在的基因多态性,再用连接酶特异检测技术在大样本进行SNP分型,并通过统计学方法分析基因多态性与结核病易感性之间相关性。结果共检测到6个基因多态性,它们在结核病患者与健康人之间等位基因和基因型上并不存在显著差异(P>0.05)。结论 TLR2基因多态性并不是中国人群结核病发病的重要危险因素。更多还原

【Abstract】 Objective To detect genetic polymorphisms in TLR2 gene specific for Chinese Han Population,and verify whether they are associated with susceptibility to pulmonary tuberculosis.Methods Search TLR2 gene polymorphisms by sequencing in small sample;detect SNPs by ligase detection reaction technique in large sample;analyze whether genetic polymorphisms are related to tuberculosis by statistic methods.Results Six genetic polymorphisms were detected,but allelic and genotypic analysis showed that there were no significant differences between pulmonary tuberculosis patients and healthy controls(P>0.05). Conclusion TLR2 genetic polymorphisms are not risk factors for pulmonary TB in Chinese Han Population.更多还原