【作者】 李娜； 王文誉； 奚剑飞； 徐皓； 丁爽爽； 张周；

【Author】 LI Na,WANG Wen-yu,XI Jian-fei,XU Hao,DING Shuang-shuang,ZHANG Zhou (Shanghai Institution of Materia Medica Chinese Academy of Science,Shanghai 201203,China )

【机构】 中国科学院上海药物研究所；

【摘要】 目的在Beagle犬侧腹部肌肉组织上埋置传感器,采用生物遥测法监测清醒状态下动物的心率、体温、血流动力学及心电图各项指标。方法手术埋置传感器,恢复两周后,采用Dataquest A.R.T 2.3系统连续监测24h内的心率、体温、血流动力学和心电图指标,并于次周重复一次。结果在整个实验过程中,该方法所监测指标基本维持正常水平,但于10:00AM部分指标升至最高,心率值达到95.58±15.89bpm,收缩压、平均动脉压及舒张压也分别升至最高达152.37±10.67mmHg、109.37±5.90 mmHg和87.73±5.01 mmHg,且两次实验及平均值间比较也没有明显差异(P>0.05)。结论体内埋置传感器方法可以更加准确的监测清醒状态下Beagle犬的各项心血管指标,且动物在饮食过程中呈现出较高兴奋的状态。更多还原

【Abstract】 Objective To monitor the heart rate、temperature、hemodynamics and electrocardiogram of clear-headed beagle dog by telemetry,with imbedding the sensor in abdomen muscle.Methods After two weeks of imbedding the sensor, monitored the heart rate temperature、hemodynamics and electrocardiogram on continuous 24 hours by Dataquest A.R.T.2.3, then repeated again next week.Results In all of the monitor process,every index maintain the normal level,but the heart rate rise to the highest about 95.58±15.89bpm at 10:00AM,as the systolic pressure、mean arterial blood pressure and diastolic pressure were 152.37±10.67mmHg、109.37±5.90 mmHg and 87.73±5.01 mmHg separately.And among the twice results and the average,they hadn’t any differences(P>0.05).Conclusions Telemetry of clear-headed beagle dog could monitor the cardiovascular targets more exactly,and the beagle dog was very excited on diet.更多还原