【作者】 吕锡宏； 杨忠东； 陈浩； 蒋懿； 居丽雯； 朱渭萍； 申惠国； 周艳冰； 蒋露芳； 施强； 姜庆五；

【Author】 LV Xi-hong YANG Zhong-dong~(2*),CHEN Hao~2,JIANG Yi~1,JU Li-wen~1,ZHU Wei-ping~3,Sheng Hui-guo~4, ZHOU Yan-bing~5,JIANG Lu-fang~1,Shi Qiang~1,Jiang Qing-wu~1.1.School of Public Health,Fudan University,The Key Laboratory of Public Health Safety,Ministry of Education,Shanghai 200032,China;2. Shanghai Institute of Biological Products,Shanghai 200052,China;3.Pudong New Area Center for Disease Control and Prevention,Shanghai 200136,China;4.Minhang District Center for Disease Control and Prevention,Shanghai 201101,China;5.Putuo District Center for Disease Control and Prevention,Shanghai 200333,China

【机构】 复旦大学公共卫生学院流行病学教研室公共卫生安全教育部重点实验室； 上海生物制品研究所； 上海市浦东新区疾病预防控制中心； 上海市闵行区疾病预防控制中心； 上海市普陀区疾病预防控制中心；

【摘要】 目的了解上海地区人群血清中季节性H1、H3亚型流感病毒抗体水平及职业人群中H5、H9亚型禽流感抗体的检出情况。方法应用血凝抑制试验(hemagglutinin inhibit test,HI-test)对上海地区2009年职业人群以及一般人群各年龄组进行H1、H3、H5、H9亚型流感病毒抗体的血清学监测。结果 A/Brisbane/59/2007(H1N1)HAI抗体阳性率,一般人群为82.8%(275/332),职业人群为73.9%(263/356);对A/Brisbane/10/2007(H3N2),一般人群为50.6%(168/332),职业人群为54.8%(195/356);人群中A/Brisbane/59/2007(H1N1)HAI抗体阳性率明显高于H3,与2008年上海地区流感病原学监测情况相吻合。不同年龄组中,6月～5岁年龄组和≥60岁的老年组A/Brisbane/59/2007(H1N1)、A/Brisbane/10/2007(H3N2)HAI抗体阳性率较低。职业人群与一般人群H5亚型HI抗体阳性率分别为4.2%(15/356)和0.3%(1/332);H9亚型HI抗体阳性率分别为34.6%(123/356)和2.4%(8/332)。结论上海地区人群对H1、H3季节性流感有较强的免疫保护,儿童和老年人群H1、H3季节性流感HAI抗体水平较低。职业人群禽流感病毒H5、H9 HAI抗体有明显升高趋势,要加强对职业人群流感样患者病原学和血清流行病学监测。更多还原

【Abstract】 Objective To know the levels of antibodies against seasonal influenza A viruses subtype H1 and H3 in Shanghai population,and antibodies against influenza A viruses subtype H5 and H9 in population which contacted with avian.Methods We carried out the serological survey on the antibodies against influenza A viruses subtype H1,H3,H5 and H9 in the general population(GP) with various age groups and the occupational population(OP) which contacted with avian by hemagglutinin inhibit test (HI).Results The positive rate of antibodies against influenza virus A/Brisbane/59/2007(H1N1) was 82.8%(275/332) and 73.9%(263/356) in GP and OP respectively,and antibodies against A/Brisbane /10/2007(H3N2) was 50.6%(168/332) and 54.8%(195/356) respectively.The positive rate of antibodies against influenza virus A/Brisbane/59/2007(H1N1) was significantly higher than that against A/Brisbane/10/2007(H3N2),which was consistent with survey on influenza viruses in Shanghai during 2008.The positive rate of antibodies against influenza virus A/Brisbane/59/2007(H1N1) and A/Brisbane /10/2007(H3N2) was lower in 6 month-5 year and≥60 age group than others.The positive rate of antibodies against influenza A virus subtype H5 was 4.2%(15/356) and 0.3%(1/332) in OP and GP respectively,and the positive rate of antibodies against influenza A virus subtype H9 was 34.6%(123/ 356) and 2.4%(8/332) respectively.Conclusions There was strong immune protect against the seasonal influenza A subtype H1 and H3 in Shanghai population,while lower in children and the elders.The levels of antibodies against influenza A viruses subtype H5 and H9 in the OP presented obviously ascending trend,so we must enhance etiological and serological survey on influenza virus in OP,especially on the patients with influenza-like illness.更多还原